acceptability than placebo; in adults, amphetamines were the only compound with better acceptability than placebo. Atomoxetine had the lowest mean effect size in children and adolescents based on clinicians' ratings, but in adults, its efficacy on ADHD core symptoms was comparable with that of methylphenidate. The large confidence interval in relation to the efficacy and tolerability of bupropion, clonidine, guanfacine, and modafinil suggests that caution should be used when interpreting these data. Another relevant finding, which requires replication in head-to-head trials, is the absence of significant differences between amphetamines and methylphenidate on the CGI-I measure.
