al., 2007). In addition, pharmacological inhibition of AKT downstream target mTOR by rapamycin has little effects on normal newborn neurons in the adult dentate gyrus (Figure 6). Consistent with this finding, rapamycin was shown to exhibit little effect on normal post-mitotic neurons in the adult dentate gyrus, despite effective suppression of the soma and dendrite hypertrophy in neurons with Pten knockout in the same animal (Zhou et al., 2009). Adult neurogenesis is known to be influenced by genetic background in adult mice (Kempermann et al., 1997) and certain strains of mice, such as 129 mouse inbred substrains, may have certain DISC1 isoforms deleted (Clapcote and Roder, 2006; Ishizuka et al., 2007; Koike et al., 2006). Interestingly, the phenotypes of DISC1 suppression, KIAA1212 overexpression or knockdown in newborn neurons in the adult brain were similar between 129S6 and C57BL/6 mice (Figure S10), further supporting our conclusions.
