The additional categories represent analogous annotations to Category 1 but without eQTL data and, thus, no known direct effect on binding. Category 2(a–c) demonstrates direct evidence of binding through ChIP-seq and DNase with either a matched PWM to the ChIP-seq factor or a DNase footprint. Category 3(a–b) is considered less confident in affecting binding due to a more incomplete set of evidence. These sites have ChIP-seq evidence and either a motif that matches the ChIP-seq data but no DNase evidence, or DNase evidence and any other motif. Finally, Categories 4–6 lack evidence of the variant actually disrupting the site of binding. These include DNase and ChIP-seq evidence (Category 4), DNase or ChIP-seq evidence (Category 5), or any single annotation not in the above categories (Category 6).
