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Chunk #51 — 4. Discussion — 4.3. Integrative interpretation of results with respect to functional significance

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Delta, theta, and alpha event-related oscillations in alcoholics during Go/NoGo task: Neurocognitive deficits in execution, inhibition, and attention processing.
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The results of the present study are discussed in view of the hypothesis stated earlier that the evoked power in the respective frequency bands would increase with increased cognitive control demand. Therefore, based on the interpretation that slow oscillations are related to activation and alpha is related to inhibition, or that its desynchronization is related to the preparatory phase of a motor response, lower slow oscillations (i.e., delta and theta) and lower alpha oscillations in alcoholics (especially lower fast alpha power only for the NoGo condition in alcoholics as observed in the present study), suggest deficits in both activation and inhibition of neural circuits underlying the desired/required behavior. This deficient processing was observed at all regions (except left-temporal regions for the NoGo condition) as evident in lower evoked delta power in alcoholics compared to controls for the Go and NoGo conditions; lower evoked theta power in alcoholics compared to controls for the Go condition at fronto-centro-parietal regions, and for the NoGo condition at fronto-central regions, respectively; lower evoked slow alpha power in alcoholics compared to controls for the Go condition