to senescence (n = 269). Expression of GHSR in prefrontal cortex was analyzed against a proxy SNP for rs2948694 (not genotyped in this sample), namely rs16845548 (1000GENOMES:phase_3_FIN; distance = 20137 bp, r2 = 1.0, D′ = 1.0), in a linear regression controlling for age, gender, postmortem interval, pH, RNA integrity number and ancestral descent. Using a dominant model [heterozygotes (n = 49) pooled with the rare homozygous group (n = 2)], we found that this SNP was significantly associated with GHSR expression with lower expression in the pooled groups compared with the more common homozygous group (β = −0.110, P = 0.020).
