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Chunk #26 — Methods — Biological annotation — Drug Repurposing Analyses.

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Multivariate genetic of 2.2 million individuals demonstrate genetic influences on substance use disorders operate via behavioral disinhibition and substance-specific risk.
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Factor genes identified by at least three methods and residual genes identified in at least one method were mapped to the 54. We queried broadly for all FDA approved drugs as well as looked specifically for following FDA approved drugs used in the medication assisted treatment (MAT) of any substance use disorder: buprenorphine, naltrexone, naloxone hydrochloride, methadone hydrochloride, acamprosate calcium, disulfiram, varenicline, bupropion hydrochloride, and baclofen.