Non-drug rewards such as money or natural rewards can provide a valuable context for investigating hypofrontality in alcohol dependence. For two possible reasons, responding in frontostriatal circuitry is likely disrupted during the processing of non-drug rewards. First, lasting, generalized hypofrontality in people suffering from addiction could be evident in neural response to a variety of reward classes, including to non-drug rewards such as money or natural rewards such as food. Changes in the dopamine system influence response to both drug rewards (i.e., the drug itself, with its rewarding effects) and non-drug rewards [15], and it is likely that the neural adaptations that occur with addiction generalize to responding in the presence of other types of reward, including natural rewards and money. Thus, hypofrontality could reflect general disruption in reward circuitry, whether responding to drug or non-drug rewards. In the case of non-drug rewards, hypofrontality could have consequences for difficulty in guiding behavior to obtain these rewards as necessary for healthy functioning [11]. Second, another possibility is that hypofrontality is particularly evident in the context of response to non-drug or natural
