Chunk #48 — Results — Attenuation in power and R2 due to imperfect CGR

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Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies.

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For EduYears we observed that the reported number of hits is in between the expected number of hits when the CGR is set to the averaged GREML estimate of 0.783 and when the CGR is set to one. Given the standard errors in the CGR estimates for EduYears, the CGR might very well be somewhat greater than 0.783, which would yield a good fit with the reported number of hits. However, as with the number of truly associated SNPs for BMI, in light of the risk of overfitting, we can make no strong claims about a slightly higher CGR of EduYears.