Next, we examined if genome-wide significant variants were associated with alcohol drinker status (never, previous, current) and alcohol intake frequency (average units of wine, beer, and spirits per week) in the UK Biobank, the largest GWAS of alcohol consumption published to date30 (N: 337,000 population-based individuals of European ancestry from a volunteer cohort in the UK aged 40-69 years old30). We also examined if GWAS variants were associated with AD in the Psychiatric Genomics Consortium’s meta-analysis of DSM-IV AD31, the largest GWAS of alcohol use disorder conducted to date (N: 14,904 AD cases and 37,944 controls from 28 studies; European, N: 46,568; African; N: 6,280).
