met. First, each weight must be greater than 0 and the mean of the weights must be 1. There are numerous sources of prior information that can motivate the weighting scheme including linkage scans, bioinformatics information, as well as previously conducted (and independent) genome-wide association signals (Roeder et al., 2007; Roeder & Wasserman, 2009). Further, the prior information can be in the form of test statistics (i.e. LOD scores, Z scores) or p-values (Roeder et al., 2006).
