Topiramate is FDA approved to treat seizure disorder, prevent migraine, and for weight loss (in combination with phentermine). A meta-analysis of the medication’s effects in AUD, which included 7 RCTs (total N=1,125), showed that topiramate was associated with a greater number of abstinent days (Hedges’ g=0.468) and lower binge drinking frequency (Hedges’ g=0.406) than placebo.18
