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Chunk #58 — Discussion — Developmental findings in ERO energy and phase locking in humans and rats

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Decreases in energy and increases in phase locking of event-related oscillations to auditory stimuli occur during adolescence in human and rodent brain.
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One limitation of our study is the question of whether the functions of the brain areas recorded from in rodents can be compared to humans. There has been much debate on the larger question of whether brain areas can be compared between species, especially whether non primate species have a prefrontal cortex that is homologous to humans (see [122] for review). In fact, it has been suggested that prefrontal cortex is present in rodents, carnivores and other orders of Class Mammalia and that mammals possess a “class common” pattern of frontal lobe organization [123]. However, it has been also suggested that specific areas of frontal cortex, such as the dorsolateral prefrontal cortex, does not have a homologue in the rat similar to what is seen in primates [122]. Another limitation of our study was that brain size differences between periadolescents and adults and between species may limit interpretation of the data even though the electrode locations were corrected for size differences. In humans it has been suggested that differences in EEG amplitude between children and adults may be due to