Regions with non-replicated SNPs depart from the genome-wide expectation of regional differences in LD patterns between Europeans and East Asians.The cumulative distributions of varLD targeted P-values after 1,000 permutations for non-replicated SNPs (n = 64, in gray) and replicated SNPs (n = 47, in blue) are shown. The median (black dashed line) and 95% empirical CI (green area) calculated for 100 groups of 47 SNPs randomly selected from across the genome are also depicted.