Chunk #32 — REGULATORY ELEMENTS IN THE UNTRANSLATED REGIONS — Genetic variants at the 3′UTR — MicroRNAs and miRNA binding sites

Source

Genetic variants in mRNA untranslated regions.

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yes

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To study polymorphisms affecting miRNA-binding sites, compared to SNP located in others regions, Lu and colleagues analysed the genotype and the mRNA expression in four populations, as part of the international HapMap Project. They found that compared to introns, 3′UTRs contain higher numbers of SNPs associated with changes in mRNA expression levels.67