of ethanol deprivation (Thielen et al., 2004). It is also noteworthy that a selective breeding program for high alcohol consumption in Wistar rats, Warsaw high-preferring (WHP) vs. Warsaw low-preferring (WLP), has resulted in rat lines with similar phenotypes as those described above (c.f., Dyr and Kostowski, 2008). Note that all of the rat lines discussed herein have a Wistar-associated genetic background, including certain foundation inbred rats of the N/Nih rat line which in turn was the foundation stock for the HAD/LAD lines. For instance, DA, and its metabolites HVA and DOPAC, levels have consistently been found to be lower in the striatum of WHP vs. WLP rats (Dyr et al., 2002). However, lower 5-HT levels in the hippocampus were observed in WHP vs. WLP rats at an early (11th), but not later (21st), generation of selection (Dyr et al., 2002).
