Replicabilities against MAFs in the discovery study.For every SNP discovered in Europeans, all the replication attempts in East Asians were considered and classified by bins of OR found in Europeans. By means of windows with step 0.3, the average statistical power (empty black circles), average replication success (solid black circles) and effective replicability (the ratio between observed and expected replicability, the two former quantities, red circles) are shown (using only windows with ≥20 attempts). Top values of the graph represent the average date of publication and sample size of discovery GWAS, for each bin of MAF.
