Chunk #8 — RESULTS — Genome-wide SNP association: primary analyses

Source

A genome-wide scan for common alleles affecting risk for autism.

Embedded

yes

Text

16q24.1rs4141463c, 20p12.1GeneHAT1POU6F2––PPP2R5CMYH11GSG1LTAF1CMACROD2Minor allele frequency0.34 (G)0.33 (G)0.31 (A)0.34 (C)0.06 (G)0.04 (A)0.43 (G)0.02 (A)0.43 (A)GroupStr|EurSpc|AllStr|AllSpc|EurSpc|EurSpc|AllSpc|EurSpc|EurStr|EurAGP discoveryORd1.641.410.611.430.540.520.690.380.5695% CI1.35–1.991.23–1.610.51–0.721.25–1.640.41–0.700.39–0.690.60–0.790.24–0.580.47–0.67P4.7 × 10−63.7 × 10−62.2 × 10−74.8 × 10−61.9 × 10−61.7 × 10−61.1 × 10−61.0 × 10−62.1 × 10−8AGREOR1.080.851.001.130.730.881.210.710.8495% CI0.86–1.370.73–0.990.83–1.220.95–1.340.52–1.020.41–1.881.03–1.430.44–1.120.67–1.04P5.2 × 10−14.6 × 10−21.0 × 10−01.8 × 10−14.1 × 10−27.1 × 10−12.9 × 10−21.0 × 10−01.3 × 10−1AGP + AGREOR1.381.130.771.290.620.560.860.480.6595% CI1.19–1.611.03–1.250.68–0.881.16–1.440.50–0.760.43–0.720.77–0.950.35–0.660.57–0.75P8.5 × 10−52.3 × 10−22.3 × 10−42.7 × 10−52.1 × 10−64.2 × 10−69.3 × 10−37.0 × 10−74.7 × 10−8AGP + SAGEOR1.321.240.761.240.590.590.800.450.6995% CI1.15–1.521.12–1.380.66–0.871.11–1.380.47–0.750.46–0.760.73–0.890.31–0.660.60–0.79P8.8 × 10−53.8 × 10−58.5 × 10−57.5 × 10−57.5 × 10−61.4 × 10−52.6 × 10−51.7 × 10−58.1 × 10−8AGP + AGRE + SAGEOR1.251.090.841.190.640.630.910.540.7395% CI1.11–1.411.00–1.180.76–0.931.10–1.300.53–0.780.50–0.790.84–0.990.40–0.730.66–0.82P2.0 × 10−44.6 × 10−21.0 × 10−35.6 × 10−52.9 × 10−65.7 × 10−52.8 × 10−22.1 × 10−53.7 × 10−8Spc, spectrum; Str, strict; All, all ancestries; Eur, European ancestry.aReporting restricted to SNPs with statistics meeting or falling below the threshold of P < 5 × 10−6. See Supplementary Material for description of all SNPs with statistics meeting or falling below the threshold of P ≤ 5 × 10−4.bBold emphasis denotes SNPs discussed.cTop association signal reported only; additional signal at reporting threshold for markers in strong LD include rs6079536, rs6079537, rs6079540, rs6079544, rs6074787, rs10446030, rs6079553, rs4814324, rs6074798, rs980319 (Supplementary Material, Table S2).dOdds ratio based