(0.015%) from which an increased saccharin preference was observed in Lwt/+ mice relative to +/+ animals (P<0.001, post hoc Tukey test) (Figure S4). We also observed increased total fluid consumption (water + quinine solution) in Lwt/+ animals. In contrast, there were no significant differences in taste sensitivity or in total fluid consumption in Control/+ B6D2 F1 animals (D.J.S., data not shown). Together, these data suggest that while ethanol preference and consumption are indeed increased in Lwt/+ mice on a B6D2 background, both increased fluid consumption and a higher propensity to prefer saccharin may contribute to this phenotype.
