The 269 putative genes that were identified as being significantly associated (P < 2.80 × 10-6) with depression using MAGMA 14 were examined for known interactions (including agonistic, partial agonistic, antagonistic, modulating, binding and blocking interactions) with prescribed medications in the Drug Gene Interaction Database v3.0. (dgidb.genome.wustl.edu) A total of 560 interactions were identified between 57 genes and 514 drugs (see Supplementary Table 11). Anatomical Therapeutic Chemical (ATC) classifications were available for 220 of these drugs which belonged to 54 different second level ATC classes and which interacted with 37 genes, Figure 3. The greatest number of drug - gene interactions (ninteractions = 47) were observed between psycholeptics (N05, which includes antipsychotics and anxiolytics) and dopamine receptor D2 (DRD2).
