correlation approach81 used for pathway analysis. Under additive assumptions, â2 is the heritability estimate h2, and P-values are reported for the right tail (positive â2) except where noted. P-values for the X-chromosome were obtained using separate heritability analysis for males and females (using identical methods as for autosomes), then combining using Fisher’s method. For the analyses in Supplementary Table 7, h2 values for the X-chromosome were obtained by ignoring twin sex, producing an approximate average across the sexes. After calculating results for all 47,628 transcripts, a unique “best-h2” set used the most significant transcript for each of the 18,293 genes, with FDR control applied to the best-h2 in a manner accounting for all transcripts.
