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Chunk #5 — Introduction — GWAS

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Interpretation of risk loci from genome-wide association studies of Alzheimer's disease.
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controls for equivalent power to traditional GWAS. However, GWAX can massively increase statistical power compared with GWAS due to a larger sample size by including younger samples from large biobanks.17 Unknown sample overlap in meta–analysis of cohort studies can lead to false associations due to recruitment of individuals into multiple studies, an issue which large-scale bio banks will exacerbate.18 Funding agencies have begun to address this issue through globally unique identifiers or similar solutions.