Chunk #9 — MATERIALS AND METHODS — Genetic association analyses

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Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.

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For all association analyses, the genotype status at each SNP was consistently coded as the number of copies of the allele that is minor in the EA sample, so the major allele in EAs is the reference. Association tests were carried out using PLINK (Purcell et al., 2007) and SAS (Cary, NC).