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Chunk #10 — METHODS — STATISTICAL ANALYSES

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Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.
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The interaction between the secondary variables (sex, birth cohort, and educational attainment) and rs16969968 on smoking behavior was evaluated by a stratified meta-analysis of CPD (coded as a 4-level trait). These results are presented in eFigures 1 to 4.