GWA is a method of choice for identifying genes whose variants influence vulnerability to complex disorders. GWA approaches that we term “template” seek to identify “genome wide” levels of significance (ca 10−7–10−8) for case vs control differences in single samples of individually genotyped individuals. “Replication” of GWA results in these “template” GWA analyses is based on identification of genome wide significance for the same SNP with the same phase of association in each of multiple independent samples.
