Chunk #115 — III. Selected Methodological Issues — C. Analyses — 2. Stepwise approaches to analyses

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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Analyses focus on genes that are identified by clustered positive results from several samples. This approach, rather than focus on individual SNPs whose informativeness might differ in different samples, allows for some degree of genetic heterogeneity and for some sample-to-sample differences in the detailed patterns of linkage disequilibrium.