Chunk #20 — Online Methods — Simulation of sequencing data based on 1000 Genomes Project dataset — Simulated phenotypes

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Extremely low-coverage sequencing and imputation increases power for genome-wide association studies.

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Starting from the typed genotype calls, we simulated continuous randomly ascertained phenotypes Y ~ gβ + ε, with ε ~ N(0,1). β = 0 represents the null model of no association between genotype and phenotype.