a variety of alcohol-related outcomes, including relapse [145]. Additionally, neuroticism has been associated with the ineffective use of coping strategies [146], while also mediating the relationship between AUD and neural connectivity [147]. Empirically, neuroticism has also been found to be associated with internalizing factors related to the lifetime diagnosis of mood and anxiety [148]. On the other hand, individuals from the memory group also reported fewer uplifting experiences than the comparative controls, reflecting less pleasurable experiences at work and home. A lack of adequate uplifting experiences represents a lower buffer against stress and reduced coping abilities [149], which can also contribute to both AUD [146,150] and internalizing outcomes such as depression [151,152]. Alternatively, negative mood states may lead to the assessment of fewer experiences as uplifting. Taken together, it is clear that personality- and life-experience-related factors are important determinants in alcohol-related outcomes, possibly mediated by neural and stress–coping dyad mechanisms. However, further studies are needed to elucidate the specific mechanisms involved in the complex etiological pathways of risk, symptoms, and recovery in AUD and related disorders.
