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Chunk #14 — Methods — Statistical Analysis

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Polygenic risk scores for alcohol involvement relate to brain structure in substance-naïve children: Results from the ABCD study.
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with each PRS. False-discovery rate (FDR) correction within modality (e.g., cortical thickness) was used to adjust for multiple testing. (Gray matter cortex = 34 regions, white matter = 36 tracts, subcortex = 26 regions). Results surviving FDR correction are discussed here; we make all results (significant and non-significant) available in the Supplement Results by region and PRS. Each brain region that was significantly associated with PRS was then tested for association with full-scale IQ, and externalizing problems.