signaling and gene expression that do not recover following enrichment during adulthood (Buwembo, Long, & Walker, 2013; El Rawas et al., 2011; Lee & Hill, 2013; Malone, Kearn, Chongue, Mackie, & Taylor, 2008; Reich, Mihalik, Iskander, Seckler, & Weiss, 2013; Sciolino et al., 2010). These sustained differences in the eCB system may leave individuals vulnerable to later psychopathology, including cannabis dependence.
