Additionally, a total of 2,058 SNPs in ARHGAP10, MARK1, DDX6, KIAA1409, CTBP2, GRM3, TBC1D2B, BACH2 and CNTNA that were significant risk genes for alcohol dependence, alcohol and nicotine co-dependence or nicotine dependence identified by Lind et al. (2010) were also tested in our samples. We listed all p values <0.01 in the Supplemental Table S3. We found that none of these markers were significantly associated with alcohol and nicotine co-dependence in our samples after Bonferroni correction.