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Chunk #17 — 3. Capturing Common Variation — 3.2 Linkage Disequilibrium

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Chapter 11: Genome-wide association studies.
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For the purposes of genetic analysis, LD is generally reported in terms of , a statistical measure of correlation. High values indicate that two SNPs convey similar information, as one allele of the first SNP is often observed with one allele of the second SNP, so only one of the two SNPs needs to be genotyped to capture the allelic variation. There are dependencies between these two statistics; is sensitive to the allele frequencies of the tow markers, and can only be high in regions of high .