confined to observations at single loci and transcripts in individual cell systems or tissues. The recent development of genome-scale technologies provides unprecedented opportunities to expand upon these experiments. The integration of genetic, epigenetic and expression data promises to provide general observations regarding the relationship between genetic variation and expression. Beyond these observations these data can be readily mined to unravel the network of effects associated with genomic variants. This may reveal some of the rather cryptic intermediate events that occur between DNA variant and phenotype.
