A GWAS of the AUDIT in nearly 8000 individuals failed to identify any GWS loci6. A GWAS of the AUDIT from 23andMe in 20,328 European ancestry participants also failed to yield GWS results7, although meta-analysis of the AUDIT in the UKBB and 23andMe samples identified 10 associated risk loci, including associations to JCAD and SLC39A13 (ref. 8). In addition to the total AUDIT-C score, the meta-analysis included GWASs for the AUDIT-C and AUDIT-P, which showed significantly different patterns of association across a number of traits, including psychiatric disorders. Specifically, the direction of genetic correlations between schizophrenia, major depressive disorder, and obesity (among others) was negative for AUDIT-C and positive for AUDIT-P.
