showed significant changes in acetylation of both H3 and H4, there was minimal (~2%) overlap between genes that showed reduced histone acetylation and those that showed increased H3 methylation after chronic cocaine (see Fig. 1A and Supplemental Table S5). These novel findings suggest that, for the vast majority of cocaine-regulated gene promoters in the NAc, activation or repression involves independent alterations in histone acetylation or methylation.
