The recent release of assembled and annotated genomes for 16 inbred mouse strains (https://www.biorxiv.org/content/early/2018/02/12/235838) and two wild-derived strains (CAROLI/EiJ and PAHARI/EiJ) (10) represent major milestones in mouse genetics and comparative genomics. MGD’s Multiple Genome Viewer (MGV; http://www.informatics.jax.org/mgv) was developed specifically to enable researchers to explore and compare chromosomal regions and synteny blocks between the C57BL/6J reference genome and the 18 other available mouse genomes (Figure 1). MGV shows corresponding regions of the user-selected genomes as horizontal stripes and the equivalent features in each genome via vertical connectors (Figure 1). The navigation of the genomes is synchronized as a user scrolls in 5′ or 3′ directions. Researchers can generate custom sets of genes and other genome features to be displayed in MGV by entering genome coordinates, function, phenotype, disease and/or pathway terms.
