Sixth, we do acknowledge that there may be regional specificity in the structure–function relationship, but previous evidence suggests that such specificity may be less for thalamo-cortical connections as well as inter-hemispheric connections between homologous regions. In addition, not all cortical regions have six layers. Therefore, it is reasonable to surmise that the broad nature of our hypotheses might have averaged out some effects and decreased their effect sizes. Testing more specific hypotheses in future studies may unravel the full extent of the utility of layer specific FC investigations.
