intensity bin. Indeed, the highest BGS intensity bin in non-LoF-intolerant genes was enriched for heritability at a level roughly equivalent to that for all LoF-intolerant genes. These findings point to BGS and LoF intolerance as making at least partially independent contributions to heritability enrichment in schizophrenia. In contrast, none of the phenotypes we selected on the basis of their minimal impact on fecundity (Alzheimer’s disease, type 2 diabetes and neuroticism) showed significant BGS enrichment for heritability either when using the BGS τc statistic of the LDSR model (minimum P > 0.22; Supplementary Table 8) or when specifically testing regions of high BGS intensity in genes that were tolerant (pLI < 0.9) of functional mutations (minimum P > 0.40).
