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Chunk #24 — Discussion

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Combined analysis of circulating β-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects.
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It should be noted that in the present study we present data from the gene analysis as expressed in genotype frequency (see Tables 1, 2, 3) in contrast to many other investigators expressing their data by means of allele frequency. This may give the impression that we report a much higher frequency of the OPRM1 A118G allele in our study population compared many other studies on the Caucasian population. However, calculation of the allele frequency in our material yields values that are in good agreement with those reported from other laboratories [46].