Gene set enrichment analyses was performed on the sets of genes impacted by de novo CNVs in SCZ, BD, and controls. The primary step was performed using “DAVID Bioinformatics Resources 6.7” website (http://david.abcc.ncifcrf.gov/) using Gene Ontology terms—biological processes (GO_BP), cellular components (GO_CC), and molecular functions (GO_MF)—including KEGG, BioCarta, BBID, and Panther pathway databases and by excluding pathway results containing < 3 CNV genes. We selected the nonredundant pathways from DAVID with p value < 0.05 for further analysis by permutation-based test.
