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Chunk #3 — Introduction

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Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence.
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We have developed a “nontemplate” strategy that identifies overall replication of sets of genome wide association (GWA) results in the face of difficulties with genetic architectures, samples and genotyping methods [9], [14], [20], [21]. Such an approach can complement meta-analyses that seek to combine data from single markers whose significance in single samples does not achieve genome wide significance.