Chunk #9 — Methods and Materials — Post-GWAS analyses

Source

Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci.

Embedded

yes

Text

To investigate shared genetic and molecular mechanisms, we tested genetic overlap (i.e., shared risk alleles) of MaxAlc with a wide range of phenotypes. Genetic correlations were calculated using the LD score regression method (https://github.com/bulik/ldsc) (24). LDSC results regarding 232 traits were extracted from the data available at LD Hub v1.4.0 (http://ldsc.broadinstitute.org/ldhub/)(25). Genetic correlations for an additional 1,547 traits were calculated using the GWAS summary association results available at https://sites.google.com/broadinstitute.org/ukbbgwasresults; these GWAS used data from ~337,000 unrelated British individuals from the UK Biobank (26).