The number of individuals needed to identify a disease-associated group depends strongly on the underlying genetic scenario. With n = nA = nU = 1000 individuals, a group with a PAR of 1% can be identified under the Recessive-Set model, while a group with a PAR of 5%–10% can be identified under the other models. A study with n = 7000 individuals can identify a group with a PAR of 2% under all genetic models (Table 1; see Tables S1 and S2 for equivalent tables for the CMC and CAST methods).
