70). Similarly, the anti-inflammatory effects of CTRP3 have also been observed in isolated primary human colonic fibroblasts (21). Combined, these data show promise for the use of CTRP3 and CTRP3-mediated pathways as a potential anti-inflammatory mediator. However, neither chronic CTRP3 deficiency nor overexpression altered the inflammatory response to a sublethal challenge to LPS (48), indicating that CTRP3 levels need to be regulated transiently to demonstrate an anti-inflammatory effect. Regardless, the potential use of CTRP3 as an inhibitor of inflammation needs to be examined in more detail.
