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Chunk #11 — Materials and Methods — Individual Difference Measures

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Initial evidence that OPRM1 genotype moderates ventral and dorsal striatum functional connectivity during alcohol cues.
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To model the shared variance between the alcohol problem indices (ADS, PACS, Symptom Count, DrInC-2R, and CIWA-Ar) principal components analyses were conducted on the full sample of problem drinkers (n = 295) to derive factor scores capturing alcohol problem severity, as described in detail elsewhere (Ray et al., 2013). Participants’ score on the single factor, labeled alcoholism severity, was used in subsequent analyses.