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Chunk #25 — Results and Discussion — Association

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The quantitative trait linkage disequilibrium test: a more powerful alternative to the quantitative transmission disequilibrium test for use in the absence of population stratification.
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Assuming 395 independent tests were performed, a 1 df χ2 statistic of 14.69 (p = 0.000127) would be required for significant evidence of association. By this criterion, none of the tests, including the measured genotype test, showed significant evidence of association for any of the SNPs in the region of linkage. The Illumina SNP rs1896887, at location 129.5 cM, yielded the highest χ2 value (11.296) for the QTDT, followed by the Affymetrix SNPs tsc0049494 (χ2 = 11.179) and tsc0022400 (χ2 = 10.507), both at a location 131.8 cM. The highest χ2 value (10.0598) for the QTLD was observed for the Affymetrix SNP tsc0510163, at location 143.6 cM.