Chunk #9 — De novo SVs: A Small Force that Packs a Large Punch

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CNVs: harbingers of a rare variant revolution in psychiatric genetics.

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Although the absolute rate of structural mutation is low, individual mutations may affect tens or thousands of kilobases. Therefore, the overall rate of genomic change (as measured in nucleotides) is high, on the order of 1,000 bp per generation, and the functional impact per site is large.