Chunk #21 — 1. Definitions and conceptual framework for compulsivity in addiction — 1.3. Animal models of compulsivity in addiction as defined by increased drug taking: Escalation in drug self-administration with prolonged access
incentive effects of cocaine as drug intake have been observed following extended access and include increased cocaine-induced reinstatement after extinction and a decreased latency to goal time in a runway model for cocaine reward (Deroche et al., 1999). Altogether, these results suggest that drug taking with extended access changes the motivation to seek the drug. Whether this enhanced drug taking reflects a sensitization of reward or a reward deficit state remains under discussion (Vezina, 2004), but the brain reward and neuropharmacological studies outlined below argue for a reward deficit state driving the increased drug taking during extended access.
