Predictive accuracy of polygenic risk scores for height at intervals along the measured height distribution in the UK Biobank.Using summary statistics from the GIANT Consortium, we computed polygenic risk scores for height and compared them to the distribution of standardized height in the UK Biobank after adjusting for sex and the first 10 principal components. However, prediction accuracy is not distributed evenly; it performs particularly poorly at the extreme short end of the height distribution, indicating a larger contribution of environmental factors, large-effect rare variants, and/or other factors in these individuals. Numbers in the plot indicate observed versus expected polygenic risk scores within corresponding breakpoints along the adjusted height distribution. Expected polygenic risk scores comes from multivariate normal simulations assuming the same correlation between adjusted height and observed polygenic risk scores.
