There is clearly scope to reduce the burden associated with cannabis dependence. The estimates presented in this paper are potentially useful for service planning at global, regional and country levels. Although cannabis use was estimated to be a smaller contributor to disease burden than alcohol or opioids, nonetheless some 2 million years lived with disability were attributed to the drug. Behavioural interventions are effective in the treatment of cannabis dependence[53,54], with cognitive behavioural therapy and contingency management showing the greatest promise. Public health campaigns may also be necessary to advise young people of the risks of developing dependence on cannabis because this risk may be underappreciated by many users.