Those findings allowed for testing Hypothesis 3. Here, in four of the seven baseline conditions where ROIs related to future alcohol problems, baseline BOLD response contrast predicted that adverse alcohol outcome above and beyond the outcome predicted by LR alone. Backward elimination regression analyses that included LR and four ROIs (right middle frontal gyrus, left anterior insula, and left middle insula) indicated that activation to affective faces in the right middle frontal gyrus and the left anterior insula were the strongest predictors of future alcohol problems.
